![]() ![]() They are all believed to be similarly effective for this purpose. Doxazosin, terazosin, alfuzosin, and tamsulosin have all been well established in treatment to reduce lower urine tract symptoms (LUTS) caused by benign prostatic hyperplasia. ![]() Alpha-1 blockers are first line treatment for the symptoms of BPH in men. Alpha-1 blockers are the most commonly used medicine to treat BPH. Medical uses Benign prostatic hyperplasia īenign prostatic hyperplasia (BPH) is an enlarged prostate gland. Drugs that act as selective antagonists at specific alpha-1 adrenergic receptor subtypes have also been developed. As of 2018, prazosin is the only alpha-1 blocker known to act as an inverse agonist at all alpha-1 adrenergic receptor subtypes whereas tamsulosin is a selective antagonist for all alpha-1 subtypes. Currently, several relatively selective alpha-1 antagonists are available. The first drug that was used was a non-selective alpha blocker, named phenoxybenzamine and was used to treat BPH. Over the last 40 years, a variety of drugs have been developed from non-selective alpha-1 antagonists to selective alpha-1 antagonists and alpha-1 inverse agonists. When alpha blockers bind to these receptors in vascular smooth muscle, they cause vasodilation. Alpha-1 adrenergic receptors are present in vascular smooth muscle, the central nervous system, and other tissues. They are mainly used to treat benign prostatic hyperplasia (BPH), hypertension and post-traumatic stress disorder. Alpha-1 blockers (also called alpha-adrenergic blocking agents or alpha-1 antagonists) constitute a variety of drugs that block the effect of catecholamines on alpha-1-adrenergic receptors. ![]()
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